Impact of preoperative portal vein thrombosis on liver transplantation
Editorial

Impact of preoperative portal vein thrombosis on liver transplantation

Yasuhiko Sugawara

Departments of Transplantation/Pediatric Surgery and Gastroenterology and Hepatology, Postgraduate School of Life Science, Kumamoto University, Kumamoto, Japan

Correspondence to: Dr. Yasuhiko Sugawara. Department of Transplantation/Pediatric Surgery, Postgraduate School of Life Science, Kumamoto University, 1-1-1 Honjo, Chuo-ku, Kumamoto 8603-8556, Japan. Email: yasusuga-tky@umin.ac.jp.

Provenance: This is a Guest Editorial commissioned by Associate Editor-in-Chief Xingshun Qi (Department of Gastroenterology, General Hospital of Shenyang Military Area, Shenyang, China).

Comment on: Karvellas CJ, Cardoso FS, Senzolo M, et al. Clinical Impact of Portal Vein Thrombosis Prior to Liver Transplantation: A Retrospective Cohort Study. Ann Hepatol 2017;16:236-436.


Received: 04 June 2017; Accepted: 08 June 2017; Published: 29 June 2017.

doi: 10.21037/amj.2017.06.06


Portal vein thrombosis (PVT) is one of the common complications of in cirrhotic patients (1). The frequency in candidates for liver transplantation will be higher. Patients listed on the liver transplantation, therefore, will undergo screening for PVT. PVT has now not to thought to be a contraindication for liver transplantation since 1990 (2). Due to progress in diagnostic tools and surgical techniques, most patients with PVT may undergo deceased-donor liver transplantation successfully (3). The patients with PVT, which is confined to the trunk of the portal vein (Yerdel’s grades I and II), are comparable with the patients without PVT in surgical outcome. Dissection of the thrombosis from the main portal trunk to the confluence of splenic vein and superior mesenteric vein is necessary. The complete dissection and removal of the thrombosis is often difficult. It is necessary to obtain a satisfactory portal flow. Ultrasound guided dissection may be useful for decreasing the risk of portal vein injury (4). In cases with more extensive PVT (Yerdel’s grade III), jump grafts to the superior mesenteric vein or to the major collateral veins had provided satisfactory survival after liver transplantation. A vein graft is anastomosed to the superior mesenteric vein, which was guided to the donor portal vein through meso-colon and pancreas head. A study by Karvellas et al. (5) compared two groups (one with PVT and the other without PVT) and found that there was no significant difference between the groups in surgical outcome.

Probably the most important findings in the present study included the prognostic factors among the patients with preoperative PVT who underwent liver transplantation. They showed that the poor outcomes and high mortality rates in the patients who had complete thrombosis [Yerdel’s grade IV (6)] preoperatively and more less advanced PVT (PVT limited in the intrahepatic or that re-canalized) was not related with postoperative mortality. The concerns in transplanting patients with PVT included the postoperative thrombosis, which was more common in non-survivor after liver transplantation (5) although postoperative use of antithrombotic therapy was not related with the prognosis. Evaluation on portal flow in closer interval is recommended in the transplanting patients with preoperative PVT.

In summary, Karvellas et al. (5) have provided an information of use on the satisfactory outcome of the patients who had preoperative portal vein thrombosis and underwent liver transplantation. Based on their findings, preoperative Yerdel’s grade IV PVT was one of the prognostic factors, suggesting such cases should be considered a relative contraindication for liver transplantation. The present study revealed that post-transplant PVT, which may be related with incomplete removal of thrombosis and unsatisfactory portal flow, was associated with mortality. Because PVT in liver transplantation setting is now common, more detailed recommendations on the indication are necessary from the other transplant centers.


Acknowledgements

None.


Footnote

Conflicts of Interest: The author has no conflicts of interest to declare.


References

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  3. Molmenti EP, Roodhouse TW, Molmenti H, et al. Thrombendvenectomy for organized portal vein thrombosis at the time of liver transplantation. Ann Surg 2002;235:292-6. [Crossref] [PubMed]
  4. Inoue Y, Sugawara Y, Tamura S, et al. Intraoperative ultrasound guided portal venous thrombectomy in living donor liver transplantation recipient surgery. Transpl Int 2008;21:428-33. [Crossref] [PubMed]
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  6. Yerdel MA, Gunson B, Mirza D, et al. Portal vein thrombosis in adults undergoing liver transplantation: risk factors, screening, management, and outcome. Transplantation 2000;69:1873-81. [Crossref] [PubMed]
doi: 10.21037/amj.2017.06.06
Cite this article as: Sugawara Y. Impact of preoperative portal vein thrombosis on liver transplantation. AME Med J 2017;2:80.

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