Article Abstract

Renal dysfunction in cirrhosis, does the baseline renal function matter?

Authors: Florence Wong


Acute renal dysfunction is a common complication of liver cirrhosis, previously thought to occur in 20% of all cirrhotic patients admitted into hospital (1), diagnosed when the serum creatinine (sCr) acutely increases by 50% to a final value ≥1.5 mg/dL (133 µmol/L). However, with the recognition that small changes in renal function can also affect patient outcomes in both cirrhotic (2) and non-cirrhotic
populations (3), the International Ascites Club recently changed the definition of renal dysfunction in cirrhosis, clearly setting out what should be regarded as acute versus chronic renal dysfunction (4), so to make the definitions more relevant in daily clinical practice.