Article Abstract

Targeting ELK1: a wELKome addition to the prostate cancer armamentarium

Authors: Jelani C. Zarif, Emmanuel S. Antonarakis

Abstract

The androgen receptor (AR) is a critical steroid receptor required for prostatic luminal cell survival. In its unbound state, AR is initially localized to the cytoplasm and has been demonstrated to interact with a host of scaffold proteins and kinases such as c-Src (1) in a non-genomic fashion (2).