TY - JOUR AU - Gohar, Farhan AU - Tripathi, Dhiraj PY - 2017 TI - Carvedilol delays the progression of small oesophageal varices in patients with cirrhosis: an unmet need finally met? JF - AME Medical Journal; Vol 2 (April 2017): AME Medical Journal Y2 - 2017 KW - N2 - Non-selective beta blocker (NSBB) therapy remains the front runner in the treatment of portal hypertension. Over the years, our understanding of their mechanisms of action, both haemodynamic and non-haemodynamic, has evolved. Variceal bleeding, an inevitable consequence of portal hypertension, accounts for 10% of all admissions with gastrointestinal bleeding, and has an inpatient mortality of 15% and 1 year mortality of up to 40% (1). Reducing the risk of the development of varices (pre-primary prophylaxis) and the first variceal bleed (primary prevention) are therefore important clinical goals. UR - https://amj.amegroups.org/article/view/3765