%0 Journal Article %T Hepatitis C antiviral therapy: the next generation %A Lun Yau, Alan Hoi %A Yoshida, Eric M. %J AME Medical Journal %D 2017 %B 2017 %9 %! Hepatitis C antiviral therapy: the next generation %K %X In less than a decade, antiviral therapy for chronic hepatitis C (HCV) has undergone dramatic change. The sustained virologic response rate (SVR), defined as HCV RNA undetectability 12 weeks post-therapy, is recognized as being a virologic “cure” and has increased from 40–50%, with peginterferon and ribavirin, to 95–99% with the newest direct acting antiviral agents (DAA) (1). Unlike the non-specific antiviral and immunostimulatory effects of interferon, DAAs specifically target the HCV replicative machinery and include protease inhibitors, NS5a inhibitors and NS5b RNA dependent polymerase inhibitors. %U https://amj.amegroups.org/article/view/3865 %V 2 %P %@ 2520-0518