%0 Journal Article %T Vitamin D and bone—the search for the optimal dose %A Grimnes, Guri %A Jorde, Rolf %J AME Medical Journal %D 2017 %B 2017 %9 %! Vitamin D and bone—the search for the optimal dose %K %X Since the discovery that cod liver oil cured rickets back in 1918, bone disease has been the hallmark of vitamin D deficiency. Still, hundreds year later, we do not know the optimal vitamin D intake or levels for our skeleton. As for most nutrients, the effects of vitamin D intake in the body follow a U-shaped pattern—with an increased risk of detrimental effects at both very low and very high intakes, with a broad range of intakes in between regarded safe and sufficient (1). What the thresholds for too little and too much should be for vitamin D, are still not clarified. %U https://amj.amegroups.org/article/view/4188 %V 2 %N 12 %P %@ 2520-0518