TY - JOUR AU - Grimnes, Guri AU - Jorde, Rolf PY - 2017 TI - Vitamin D and bone—the search for the optimal dose JF - AME Medical Journal; December 2017 Y2 - 2017 KW - N2 - Since the discovery that cod liver oil cured rickets back in 1918, bone disease has been the hallmark of vitamin D deficiency. Still, hundreds year later, we do not know the optimal vitamin D intake or levels for our skeleton. As for most nutrients, the effects of vitamin D intake in the body follow a U-shaped pattern—with an increased risk of detrimental effects at both very low and very high intakes, with a broad range of intakes in between regarded safe and sufficient (1). What the thresholds for too little and too much should be for vitamin D, are still not clarified. UR - http://amj.amegroups.com/article/view/4188