%0 Journal Article %T Immune tolerant HBV and HCC: time to revise our tolerance levels for therapy? %A Zhou, Kali %A Terrault, Norah %J AME Medical Journal %D 2018 %B 2018 %9 %! Immune tolerant HBV and HCC: time to revise our tolerance levels for therapy? %K %X The immune tolerant (IT) phase, the first phase of chronic hepatitis B virus (HBV) infection, has historically been perceived as a benign period in the natural history of this disease. Perinatal infection leads to a prolonged IT phase, with transition to immune clearance with seroconversion to anti-HBe in the second to third decade, whereas immediate progression to immune clearance usually occurs in newly infected children and adults (1). %U https://amj.amegroups.org/article/view/4306 %V 3 %P %@ 2520-0518