Showing one’s true CALRs: spleen size and platelet count help refine the molecular diagnostic pathway for patients with splanchnic vein thrombosis

The classical Philadelphia chromosome-negative myeloproliferative neoplasms (MPN) of polycythaemia vera (PV), essential thrombocythemia (ET), and primary myelofibrosis (PMF) are myeloid disorders characterized by clonal expansion of mature hematopoietic cells, extra-medullary hematopoiesis and clinically by increased incidence of thrombosis, hemorrhage and the potential to transform to acute leukemia (1).