Article Abstract

Single-institutions experience with acute kidney injury in the brain injury population

Authors: David Parizh, Vadim Meytes, Ami Patel


Background: Treatment of traumatic brain injury (TBI) in the hospital-setting focuses on prevention of the secondary insult sustained from elevated intracranial pressures. Hypertonic saline (HTS) as well as other agents are employed as part of the medical management armamentarium. A retrospective chart review was performed to analyze if more aggressive resuscitation with HTS can be tolerated by assessing the rate of acute kidney injury (AKI) using the Acute Kidney Injury Network (AKIN) criteria.
Methods: Retrospective review of prospectively collected data from January 2012 through December 2014 was performed on 157 patients. AKIN criteria were used to assess for AKI.
Results: In total, 93.6% of patients did not meet any AKIN criteria.
Conclusions: AKI is an uncommon adverse effect of HTS use. Aggressive resuscitation with HTS may be tolerated and shorten the time to treatment by reaching therapeutic sodium levels more expeditiously.